Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury
Retinal IR injury activates caspase-11 non-canonical inflammasomes in glial cells of the retina. This results in increased protein levels of GSDMD and IL-1β and leads to damage in the inner layer of the retina.
Authors
- Yong Wan (ORCID: https://orcid.org/0000-0003-1160-4240)
- Cheng Pei (ORCID: https://orcid.org/0000-0003-2805-728X)
- Yun Qi (ORCID: https://orcid.org/0000-0002-8838-8577)
- Jiayu Li (ORCID: https://orcid.org/0000-0002-2755-6549)
- Jing Yang (ORCID: https://orcid.org/0000-0001-8929-5391)
- Jialei Pu
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s10020-024-00938-0
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Natural Science Foundation of China
- Natural Science Basic Research Program of Shaanxi Province