Pregnane X receptor reduces particulate matter-induced type 17 inflammation in atopic dermatitis
In summary, PM exposure induces type 17 inflammation and PXR activation in AD. PXR activation reduces PM-induced type 17 inflammation by suppressing the NF-κB signaling pathway. Thus, PXR represents a promising therapeutic target for controlling the PM-induced AD aggravation.
Authors
- Ji Su Lee (ORCID: https://orcid.org/0000-0003-0207-2107)
- Soyun Cho (ORCID: https://orcid.org/0000-0003-2468-485X)
- Youngae Lee
- Sunhyae Jang (ORCID: https://orcid.org/0000-0001-7745-8130)
- Jang-Hee Oh
- Dong Hun Lee
Institutions
- Seoul National University (KR)
- Seoul Metropolitan Government (KR)
- Seoul National University Hospital (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3389/fimmu.2024.1415350
- Citations
- 1
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.53
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Education, Science and Technology