Morusin, a novel inhibitor of ACLY, induces mitochondrial apoptosis in hepatocellular carcinoma cells through ROS-mediated mitophagy
Collectively, our findings highlight Mor as a potent bioactive inhibitor of ACLY and a promising candidate for HCC therapy.
Authors
- Guanqing Zhang (ORCID: https://orcid.org/0009-0000-3610-2074)
- Tao Lu (ORCID: https://orcid.org/0000-0002-2030-3813)
- Maolei Xu (ORCID: https://orcid.org/0000-0001-5318-1018)
- Xiaoqing Yuan (ORCID: https://orcid.org/0000-0002-5376-3162)
- Ling Hui Zhou (ORCID: https://orcid.org/0000-0001-9868-2561)
- Huan Liu (ORCID: https://orcid.org/0000-0002-0253-647X)
- Xiaohan Liu (ORCID: https://orcid.org/0000-0002-1154-8122)
- Desheng Li (ORCID: https://orcid.org/0000-0002-2171-2459)
- Jianjun Ma (ORCID: https://orcid.org/0000-0003-2527-0026)
- Yue Wang (ORCID: https://orcid.org/0009-0002-4473-5167)
- Qiqiang Xie
- Jin-Jin Zhang (ORCID: https://orcid.org/0000-0001-9261-6571)
Institutions
- Shandong University of Aeronautics (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- People's Liberation Army 401 Hospital (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.biopha.2024.117510
- Citations
- 16
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China