Predictive nomogram of the clinical outcomes of colorectal cancer based on methylated SEPT9 and intratumoral IL-10+ Tregs infiltration
The combination risk model of peripheral mSETP9 and intratumoral IL-10<sup>+</sup> Treg infiltration in CRC can effectively predict prognosis, responsiveness to 5-FU-based chemotherapy and PD-1 blockade, and the probability of recurrence or metastasis. Therefore, this model can be used for precision treatment of CRC.
Authors
- Songli Shi (ORCID: https://orcid.org/0000-0003-3128-6497)
- Chao Sun (ORCID: https://orcid.org/0000-0001-6353-5385)
- Xiaohui Yang (ORCID: https://orcid.org/0000-0001-5175-5209)
- Jie Sun (ORCID: https://orcid.org/0000-0002-0932-7195)
- Jing Xu (ORCID: https://orcid.org/0000-0002-4713-2807)
- Shiwu Zhang (ORCID: https://orcid.org/0000-0002-5052-2283)
- Zhengduo Yang
- Jiangping Wang
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Union Hospital (HK)
- Nankai University (CN)
- Tianjin Medical University General Hospital (CN)
- Tianjin People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12967-024-05635-4
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Science Foundation
- National Natural Science Foundation of China