Effects of Vitamin D on tumor cell proliferation and migration, tumor initiation and anti-tumor immune response in head and neck squamous cell carcinomas
The findings of our study highlight the promising potential of Vitamin D in the therapeutic repertoire for HNSCC patients given its immune modulating, anti-proliferative and anti-migratory properties. Clinical transferability of those in vitro and in vivo effects should be further validated in clinical trials.
Authors
- Jana Schnatmann
- Michael D. Menger (ORCID: https://orcid.org/0000-0002-9670-7961)
- Fengshen Kuo (ORCID: https://orcid.org/0000-0003-1797-2896)
- Silke Wemmert
- Maximilian Linxweiler (ORCID: https://orcid.org/0000-0002-5028-9282)
- Jan-Philipp Kühn
- Sandrina Körner (ORCID: https://orcid.org/0000-0002-6435-2940)
- Moritz Knebel
- Michael F. Holick (ORCID: https://orcid.org/0000-0001-6023-9062)
- Luc G.T. Morris (ORCID: https://orcid.org/0000-0002-4417-2280)
- Felix Leon Braun (ORCID: https://orcid.org/0009-0004-4360-0935)
- Bernhard Schick
- Lukas Brust
Institutions
- Boston University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Saarland University (DE)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.biopha.2024.117497
- Citations
- 8
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.40
Funders
- Cycle for Survival
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung
- Universität des Saarlandes
- Marie-Josée and Henry R. Kravis Center for Molecular Oncology
- National Cancer Institute