METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through cellular autophagy and senescence
METTL3 induces senescence in DC by destabilizing SIRT1 mRNA in an m6A-YTHDF2-dependent manner. The METTL3-YTHDF2-SIRT1 axis is a key target and potential pathogenic mechanism in DC.
Authors
- Nan Zhou (ORCID: https://orcid.org/0000-0002-1433-375X)
- Su Dong (ORCID: https://orcid.org/0000-0002-2342-5891)
- Yushan Fu
- Dawei Sun (ORCID: https://orcid.org/0000-0001-6925-2001)
- Jian‐Feng Chen (ORCID: https://orcid.org/0000-0003-1947-0603)
- Jiajia Zhang (ORCID: https://orcid.org/0000-0003-0385-9278)
- Yanhua Qi
- Gege Tang
Institutions
- Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12967-024-05691-w
- Citations
- 23
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.38
Funders
- Harbin Medical University
- Second Affiliated Hospital of Harbin Medical University
- China Primary Health Care Foundation
- Natural Science Foundation of Heilongjiang Province