Survival advantage of native and engineered T cells is acquired by mitochondrial transfer from mesenchymal stem cells
Artificial MitoT prevents STS-induced apoptosis of human CD3<sup>+</sup> T cells by interfering with the caspase pathway. Furthermore, we observed that MitoT confers protection to apoptosis induced by electroporation in MitoT<sup>pos</sup> CAR T-engineered cells, potentially improving their metabolic fitness and resistance to environmental stress. These results widen the physiological perspective of organelle-based therapies in immune conditions while offering potential avenues to enhance CAR-T treatment outcomes where their viability is compromised.
Authors
- Fernando Figueroa (ORCID: https://orcid.org/0000-0002-9387-094X)
- Pablo Castro-Córdova (ORCID: https://orcid.org/0000-0002-3370-4878)
- Emmanuel Arthur Albuquerque Aragão (ORCID: https://orcid.org/0009-0004-7878-5458)
- Maroun Khoury (ORCID: https://orcid.org/0000-0002-9965-6266)
- Martín Bonamino (ORCID: https://orcid.org/0000-0002-4416-5822)
- Angela C. Court (ORCID: https://orcid.org/0000-0003-1185-5728)
- Luiza Abdo (ORCID: https://orcid.org/0000-0003-4381-9123)
- Eliseo Parra-Crisóstomo
- Rocío Lorca
Institutions
- Universidad de Los Andes, Chile (CL)
- Clínica Las Condes (CL)
- Cells Therapy (Poland) (PL)
- Instituto Nacional de Câncer - INCA (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12967-024-05627-4
- Citations
- 15
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 6.57
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Agencia Nacional de Investigación y Desarrollo