Utility of IMP3, p53, and S100P immunohistochemical stains in distinguishing reactive atypia from dysplasia in cholecystectomy specimens
In challenging cholecystectomies, IMP3 positivity or aberrant p53 expression may serve as a useful adjunct to support a diagnosis of dysplasia over reactive atypia.
Authors
- Dipti M. Karamchandani (ORCID: https://orcid.org/0000-0002-0351-2859)
- Karen T. Shore
- Kara Chan Phelps
- Suntrea T.G. Hammer (ORCID: https://orcid.org/0000-0002-3384-8257)
- Purva Gopal (ORCID: https://orcid.org/0000-0001-7125-695X)
- Limin Yang (ORCID: https://orcid.org/0000-0003-1021-3942)
- James Mitchell (ORCID: https://orcid.org/0000-0002-5987-113X)
- Evan Sica
Institutions
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- Incyte (United States) (US)
Publication Details
- Journal
- Diagnostic Pathology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s13000-024-01550-w
- Citations
- 2
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- National Institutes of Health
- National Cancer Institute