Evaluating ECM stiffness and liver cancer radiation response via shear-wave elasticity in 3D culture models
The findings underscore the significant influence of ECM stiffness on liver cancer's response to radiation. Sonoporation-aided LOX inhibition emerges as a promising strategy to mitigate stiffness-related resistance, offering potential improvements in liver cancer treatment outcomes.
Authors
- Jason Chia‐Hsien Cheng (ORCID: https://orcid.org/0000-0002-2007-0220)
- Shao-Lun Lu (ORCID: https://orcid.org/0000-0001-7056-1899)
- Kun Han (ORCID: https://orcid.org/0000-0001-6181-2203)
- Wei‐Wen Liu (ORCID: https://orcid.org/0000-0002-4608-1892)
- Pei Yu
- Pai-Chi Li
Institutions
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- National Taipei University (TW)
Publication Details
- Journal
- Radiation Oncology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s13014-024-02513-7
- Citations
- 1
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Health Research Institutes