Single-Arm Clinical Study of Combination Perindopril-Amlodipine Tablets in the Treatment of High-Altitude Hypertension

Objective: To evaluate the efficacy of combination perindopril/amlodipine tablets in patients with high-altitude hypertension who were previously unable to control their blood pressure with monotherapy. Methods: A total of 151 patients with high-altitude hypertension whose blood pressure remained inadequately controlled with previous monotherapy were enrolled in this study. All patients received an 8-week treatment with a combination of perindopril/amlodipine tablets, consisting of perindopril 10 mg/day and amlodipine 5 mg/day. Blood pressure measurements, including both diastolic and systolic pressures, were taken at baseline, and after 2, 4, 6, and 8 weeks of treatment. Results: After 8 weeks of treatment, there was a significant reduction in both average systolic and diastolic blood pressure compared to baseline (P < 0.0001). Specifically, the average systolic blood pressure decreased by 24.45 ± 13.75 mmHg, and the average diastolic blood pressure decreased by 13.37 ± 8.40 mmHg. The overall heart rate showed no significant changes during the treatment period. Conclusion: A combination of perindopril/amlodipine tablets significantly improved blood pressure control in patients with high-altitude hypertension after 8 weeks of treatment. These results support the efficacy of combination perindopril/amlodipine as a viable treatment option for high-altitude hypertension.