Indoxyl sulfate induces retinal microvascular injury via COX-2/PGE2 activation in diabetic retinopathy
Our study demonstrated that indoxyl sulfate (IS), a uremic toxin originating from the gut microbiota product indole, increased significantly and contributed to retinal microvascular damage in diabetic retinopathy (DR). Mechanistically, IS impaired retinal microvascular integrity by inducing the expression of COX-2 and the production of PGE<sub>2</sub>. Consequently, targeting the gut microbiota or the PGE<sub>2</sub> pathway may offer effective therapeutic strategies for the treatment of DR.
Authors
- Gongyi Chen
- Hongyan Sun (ORCID: https://orcid.org/0000-0003-0140-6785)
- Cunzi Li
- Zhenyou Jiang (ORCID: https://orcid.org/0000-0002-9941-2990)
- Mingming Yang (ORCID: https://orcid.org/0000-0003-4484-0979)
- Xurui Wang (ORCID: https://orcid.org/0009-0002-2620-3255)
- Shu Yang (ORCID: https://orcid.org/0000-0002-4912-777X)
- Ting Meng
- Dan Liu (ORCID: https://orcid.org/0000-0001-6239-3899)
- Lan Zhou
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Jinan University (CN)
- Southern University of Science and Technology (CN)
- ShenZhen People’s Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12967-024-05654-1
- Citations
- 7
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- Natural Science Foundation of Shenzhen City