Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism
Our findings indicate that genetic liability in autism is both sex- and phenotype-dependent, expanding the current understanding of autism's genetic complexity. Our work further suggests that family-based assessments of sex differences can help unravel underlying sex-differential liability in autism.
Authors
- Yoojeong Lee (ORCID: https://orcid.org/0000-0002-7924-0247)
- Eunjoon Kim (ORCID: https://orcid.org/0000-0001-5518-6584)
- Jungeun Ji
- Soo-Whee Kim
- Donna M. Werling (ORCID: https://orcid.org/0000-0001-7731-0873)
- Ji Son (ORCID: https://orcid.org/0000-0002-5130-4763)
- Anders D. Børglum (ORCID: https://orcid.org/0000-0001-8627-7219)
- Ye Rim Kim
- F. Kyle Satterstrom (ORCID: https://orcid.org/0000-0001-6187-7680)
- Joon‐Yong An (ORCID: https://orcid.org/0000-0001-8839-6297)
- Jakob Grove (ORCID: https://orcid.org/0000-0003-2284-5744)
- Santhosh Girirajan (ORCID: https://orcid.org/0000-0003-0598-4945)
- Junehawk Lee (ORCID: https://orcid.org/0000-0001-8908-0884)
- Gang‐Hee Lee (ORCID: https://orcid.org/0000-0001-8093-0395)
- Hyeji Lee
- Jae Hyun Han (ORCID: https://orcid.org/0000-0003-3994-3463)
- Jeewon Lee (ORCID: https://orcid.org/0000-0001-5930-1834)
- Jeong Ho Lee (ORCID: https://orcid.org/0000-0002-2299-630X)
- Jung Woo Park (ORCID: https://orcid.org/0000-0001-8230-1787)
- So Hyun Kim (ORCID: https://orcid.org/0000-0003-4269-0866)
- Jae-Won Kim (ORCID: https://orcid.org/0000-0001-8821-6225)
- Hee Jung Byun
- Hee Jeong Yoo (ORCID: https://orcid.org/0000-0003-0521-2718)
- Ashish Jung
- Da Yea Song
- Eun-Ha Kim
Institutions
- Broad Institute (US)
- Pennsylvania State University (US)
- University of Wisconsin–Madison (US)
- Seoul National University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Korea University (KR)
- Aarhus University (DK)
- Soonchunhyang University (KR)
- Seoul National University Bundang Hospital (KR)
- Massachusetts General Hospital (US)
- Institute for Basic Science (KR)
- Seoul National University Children's Hospital (KR)
- Lundbeck Foundation (DK)
- Korea University (JP)
- Korea Institute of Science & Technology Information (KR)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s13073-024-01385-6
- Citations
- 23
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 7.88
Funders
- Simons Foundation Autism Research Initiative
- National Research Foundation
- Korea University
- Korea Institute of Science and Technology
- Korea Institute of Science and Technology Information
- Institute for Basic Science