Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts
The inclusion of exposure variables adds to the predictive power of MRS. Classification-based MRS may be useful in predicting risk of future PTSD in populations with anticipated trauma exposure. As more data become available, including additional molecular, environmental, and psychosocial factors in these scores may enhance their accuracy in predicting PTSD and, relatedly, improve their performance in independent cohorts.
Authors
- Mark W. Miller (ORCID: https://orcid.org/0000-0001-6393-8563)
- Agaz H. Wani (ORCID: https://orcid.org/0000-0002-0540-2952)
- Jasmeet P. Hayes (ORCID: https://orcid.org/0000-0002-5157-0666)
- Elbert Geuze (ORCID: https://orcid.org/0000-0003-3479-2379)
- Allison E. Aiello (ORCID: https://orcid.org/0000-0001-7029-2537)
- Jurjen J. Luykx (ORCID: https://orcid.org/0000-0002-6439-2774)
- Caroline M. Nievergelt (ORCID: https://orcid.org/0000-0001-5766-8923)
- Mieke Verfaellie (ORCID: https://orcid.org/0000-0001-5535-4584)
- Sheila A. M. Rauch (ORCID: https://orcid.org/0000-0001-9686-4011)
- Bart P. F. Rutten (ORCID: https://orcid.org/0000-0002-9834-6346)
- Adam X. Maihofer (ORCID: https://orcid.org/0000-0003-4517-1623)
- Christiaan H. Vinkers (ORCID: https://orcid.org/0000-0003-3698-0744)
- Shareefa Dalvie (ORCID: https://orcid.org/0000-0003-2333-4823)
- Mary Sophia Mufford (ORCID: https://orcid.org/0000-0002-8409-9217)
- Chia‐Yen Chen (ORCID: https://orcid.org/0000-0001-9548-5597)
- William Milberg (ORCID: https://orcid.org/0000-0002-6078-7066)
- Marco P. Boks (ORCID: https://orcid.org/0000-0001-6163-7484)
- Eric Vermetten (ORCID: https://orcid.org/0000-0003-0579-4404)
- Şeyma Katrinli (ORCID: https://orcid.org/0000-0003-1575-8642)
- Adriana Lori (ORCID: https://orcid.org/0000-0001-8686-0148)
- Ronald C. Kessler (ORCID: https://orcid.org/0000-0003-4831-2305)
- Nastassja Koen (ORCID: https://orcid.org/0000-0002-1119-8142)
- Leslie A. Brick (ORCID: https://orcid.org/0000-0002-1877-2493)
- Derek E. Wildman (ORCID: https://orcid.org/0000-0002-6374-5136)
- Erin B. Ware (ORCID: https://orcid.org/0000-0003-4731-8158)
- Erika J. Wolf (ORCID: https://orcid.org/0000-0003-2666-2435)
- Dan Joseph Stein (ORCID: https://orcid.org/0000-0001-7218-7810)
- Kerry James Ressler (ORCID: https://orcid.org/0000-0002-5158-1103)
- Murray B. Stein (ORCID: https://orcid.org/0000-0001-9564-2871)
- Israel Liberzon (ORCID: https://orcid.org/0000-0002-4990-556X)
- Robert J. Ursano (ORCID: https://orcid.org/0000-0002-1861-9173)
- Alicia K. Smith (ORCID: https://orcid.org/0000-0002-8537-5156)
- Anthony P. King (ORCID: https://orcid.org/0000-0002-0764-9625)
- Nikolaos P. Daskalakis (ORCID: https://orcid.org/0000-0003-1660-9112)
- Dewleen G. Baker (ORCID: https://orcid.org/0000-0002-1736-9838)
- Anthony S. Zannas (ORCID: https://orcid.org/0000-0002-6897-9652)
- Catherine Fortier (ORCID: https://orcid.org/0000-0002-6475-5336)
- Xiang Zhao (ORCID: https://orcid.org/0000-0003-1720-5996)
- Mark W Logue
- Nicole R Nugent
- Victoria B Risbrough
- Monica Uddin
Institutions
- Broad Institute (US)
- Boston University (US)
- University of North Carolina at Chapel Hill (US)
- Biogen (United States) (US)
- Western Cape Department of Health (ZA)
- Harvard University (US)
- Uniformed Services University of the Health Sciences (US)
- Emory University (US)
- University of Cape Town (ZA)
- University of South Florida (US)
- Brown University (US)
- Veterans Health Administration (US)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- McLean Hospital (US)
- VA Boston Healthcare System (US)
- University Medical Center Utrecht (NL)
- University of California San Diego (US)
- Ministry of Defence (NL)
- VA San Diego Healthcare System (US)
- National Center for PTSD (US)
- Amsterdam Neuroscience (NL)
- Geriatric Research Education and Clinical Center (US)
- Institute for Behavioral Medicine (US)
- Amsterdam University Medical Centers (NL)
- Institute for Social Research (NO)
- Stanley Center for Psychiatric Research
- The Ohio State University (US)
- New York University (US)
- Columbia University (US)
- Vrije Universiteit Amsterdam (NL)
- University of the Western Cape (ZA)
- Texas A&M University (US)
- Bryan College (US)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12920-024-02002-6
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- U.S. Department of Defense
- U.S. Department of Health and Human Services
- U.S. Department of Veterans Affairs
- Bill and Melinda Gates Foundation
- National Institutes of Health
- National Center for PTSD, U.S. Department of Veterans Affairs
- National Institute of Mental Health
- National Center for Advancing Translational Sciences