A preliminary study of sirtuin-1 on angiotensin II-induced senescence and inflammation in abdominal aortic aneurysms
Taken together, our results indicate that SIRT1 overexpression attenuates the inflammatory and senescent responses of HASMCs in the Ang II-induced AAA cell model. This finding suggests that SIRT1 can be a highly promising target for clinical treatment of AAA.
Authors
- Jinhua Mei
- Jin Yang (ORCID: https://orcid.org/0009-0001-6263-0695)
- Yuefeng Zhu (ORCID: https://orcid.org/0000-0002-7625-1856)
- Xiangyu Zhang (ORCID: https://orcid.org/0000-0001-6058-8537)
- Huanhuan Chen (ORCID: https://orcid.org/0000-0002-3918-384X)
- Kai Liang (ORCID: https://orcid.org/0000-0002-9949-5044)
- Tianshu Pang
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2024-09-27
- DOI
- https://doi.org/10.25259/cytojournal_80_2024
- Citations
- 3
- Primary Topic
- Antioxidant Activity and Oxidative Stress
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- Natural Science Foundation of Zhejiang Province