Longitudinal association of peripheral blood DNA methylation with liver fat content: distinguishing between predictors and biomarkers
Blood DNAm at SREBF1, ABCG1, DHCR24, CPT1A, and LINC00649 may be predictors of subsequent LFC change. The effects of DNAm at SREBF1 and ABCG1 on LFC were partially influenced by obesity. The findings have potential implications in understanding disease pathogenesis and highlight the potential of DNAm for early detection or intervention of fatty liver.
Authors
- Mingfeng Xia (ORCID: https://orcid.org/0000-0002-5650-0165)
- Hailuan Zeng (ORCID: https://orcid.org/0000-0001-9353-6565)
- Hui Ma (ORCID: https://orcid.org/0000-0002-6234-4699)
- Wenran Li (ORCID: https://orcid.org/0000-0002-1712-6895)
- Lingyan Chen
- Xīn Gào (ORCID: https://orcid.org/0000-0003-0108-6961)
- Jieyu Ge (ORCID: https://orcid.org/0000-0002-1070-2087)
- Huandong Lin (ORCID: https://orcid.org/0000-0002-4266-3799)
- Baishen Pan
- Sijia Wang (ORCID: https://orcid.org/0009-0000-7308-264X)
Institutions
- Sun Yat-sen University (CN)
- Kunming Institute of Zoology (CN)
- Fudan University (CN)
- Shanghai Institute of Nutrition and Health (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- University of Chinese Academy of Sciences (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12944-024-02304-9
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Fudan University