Empagliflozin alleviates obesity-related cardiac dysfunction via the activation of SIRT3-mediated autophagosome formation
EMPA promotes SIRT3-mediated autophagosome formation to alleviate damage to the cardiac structure and function of obese mice. Activated SIRT3 initiates autophagy through AMPK/Beclin1 and further stimulates elongation of the autophagosome membrane via ATG4B/ATG5. These results provide a new explanation for the cardioprotective benefits of EMPA in obesity.
Authors
- Chengxia Kan
- Hongwei Song (ORCID: https://orcid.org/0000-0003-3897-5789)
- Ningning Hou (ORCID: https://orcid.org/0000-0002-3813-8465)
- Hongzhan Tian
- Xiaodong Sun (ORCID: https://orcid.org/0000-0001-7775-2823)
- Youhong Luo
- Tongtong Ye
- Jingwen Zhang (ORCID: https://orcid.org/0000-0002-6064-1374)
- Fang Han
Institutions
- Weifang Medical University (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12944-024-02293-9
- Citations
- 9
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China