Higher prevalence of poor prognostic markers at a younger age in adult patients with myelodysplastic syndrome – evaluation of a large cohort in India
The most significant finding of this cytogenetic analysis of MDS in India is that abnormal karyotypes with poor prognosis markers including monosomy 7 and CK were more frequent than in most other reports, among patients who were overall younger. Trisomy 8, deletion 20q, the IPSS-R intermediate-risk and both high-risk groups were more common than in the West. Trisomy 8 was less common than in South-East Asia while CK and deletion 20q were comparable. Evaluation of such large cohorts highlights the unique features of MDS in different parts of the world. These findings suggest that there could be differences in predisposing factors, environmental or genetic, and emphasise the need for further exploration to better understand the varied nature of MDS.
Authors
- Anup J. Devasia (ORCID: https://orcid.org/0000-0002-3587-8601)
- Aby Abraham (ORCID: https://orcid.org/0000-0002-2596-4434)
- Alok Srivastava (ORCID: https://orcid.org/0000-0001-5032-5020)
- N. A. Fouzia
- Melvin Joy (ORCID: https://orcid.org/0000-0001-9323-994X)
- Anu Korula (ORCID: https://orcid.org/0000-0003-3207-3370)
- Sukesh C. Nair (ORCID: https://orcid.org/0000-0002-3760-0929)
- Lakshmanan Jeyaseelan (ORCID: https://orcid.org/0000-0002-9090-3005)
- Uday Kulkarni (ORCID: https://orcid.org/0000-0003-2230-2424)
- Kavitha M. Lakshmi (ORCID: https://orcid.org/0000-0002-7870-8020)
- Vivi M. Srivastava (ORCID: https://orcid.org/0009-0009-4923-4012)
- Marie-Therese Manipadam
Institutions
- Christian Medical College, Vellore (IN)
- Mohammed Bin Rashid University of Medicine and Health Sciences (AE)
- Christian Medical College (IN)
- Newcastle University (GB)
Publication Details
- Journal
- Molecular Cytogenetics
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s13039-024-00687-z
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91