Anisodamine (654-1/654-2) ameliorates septic kidney injury in rats by inhibiting inflammation and apoptosis
This study suggested that 654-1/654-2 could alleviate AKI in septic shock rats by improving inflammation invasion and cell apoptosis. Notably, 654-1/654-2 collectively suppressed inflammation response through the p38/JNK/AP-1/NF-κB pathway. Additionally, 654-1 promotes survival signaling via the Pi3K/Akt/Bcl-2 pathway, whereas 654-2 reduces apoptosis through the P53/Bax pathway. These findings provided a theoretical basis for the clinical application of 654-1/654-2 in treating organ damage caused by septic shock.
Authors
- Hui Ao (ORCID: https://orcid.org/0000-0001-5763-6147)
- Feng Wan (ORCID: https://orcid.org/0000-0002-4682-1643)
- Fei Tang (ORCID: https://orcid.org/0000-0003-1475-5028)
- Jingnan Zhang (ORCID: https://orcid.org/0000-0002-4865-5212)
- Dong Liu (ORCID: https://orcid.org/0000-0003-0451-5979)
- Li Zhang (ORCID: https://orcid.org/0000-0002-3617-2627)
- Cheng Peng (ORCID: https://orcid.org/0000-0002-8891-1401)
- Xiao-Lan Zhao
- Li-Yue Xu
Institutions
- China National Pharmaceutical Group Corporation (China) (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3389/fphar.2024.1421551
- Citations
- 2
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.93
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- Chengdu University of Traditional Chinese Medicine
- Jiangxi University of Traditional Chinese Medicine
- Chengdu University
- Sichuan Provincial Administration of Traditional Chinese Medicine