Selective regulation of macrophage lipid metabolism via nanomaterials’ surface chemistry
Understanding the interface between nanomaterials and lipoproteins is crucial for gaining insights into their impact on lipoprotein structure and lipid metabolism. Here, we use graphene oxide (GOs) nanosheets as a controlled carbon nanomaterial model to study how surface properties influence lipoprotein corona formation and show that GOs have strong binding affinity with low-density lipoprotein (LDL). We use advanced techniques including X-ray reflectivity, circular dichroism, and molecular simulations to explore the interfacial interactions between GOs and LDL. Specifically, hydrophobic GOs preferentially associate with LDL's lipid components, whereas hydrophilic GOs tend to bind with apolipoproteins. Furthermore, these GOs distinctly modulate a variety of lipid metabolism pathways, including LDL recognition, uptake, hydrolysis, efflux, and lipid droplet formation. This study underscores the importance of structure analysis at the nano-biomolecule interface, emphasizing how nanomaterials' surface properties critically influence cellular lipid metabolism. These insights will inspire the design and application of future biocompatible nanomaterials and nanomedicines.
Authors
- Shijiao Li (ORCID: https://orcid.org/0009-0000-2549-6397)
- Shengtao Yu (ORCID: https://orcid.org/0009-0003-6954-599X)
- Liang Yan (ORCID: https://orcid.org/0000-0003-2925-5544)
- Rui Cai (ORCID: https://orcid.org/0000-0002-1534-9470)
- Didar Baimanov (ORCID: https://orcid.org/0000-0002-5805-3303)
- Yalin Cong (ORCID: https://orcid.org/0000-0003-4709-4908)
- Junguang Wu (ORCID: https://orcid.org/0000-0002-9666-6549)
- Jing Wang (ORCID: https://orcid.org/0000-0001-8369-7453)
- Wei Bu (ORCID: https://orcid.org/0000-0002-9996-3733)
- Guoqing Hu (ORCID: https://orcid.org/0000-0001-9451-5336)
- Chunying Chen (ORCID: https://orcid.org/0000-0002-6027-0315)
- Xuan Bai (ORCID: https://orcid.org/0000-0001-5593-9427)
- Binhua Lin (ORCID: https://orcid.org/0000-0001-5932-4905)
- Peiyu Quan (ORCID: https://orcid.org/0000-0003-3338-5106)
- Liming Wang (ORCID: https://orcid.org/0000-0003-1382-9195)
- Yang Li (ORCID: https://orcid.org/0000-0001-7242-4687)
- Yuliang Zhao (ORCID: https://orcid.org/0000-0002-9586-9360)
- Yu Chong (ORCID: https://orcid.org/0000-0002-8634-4343)
- Yong Guan (ORCID: https://orcid.org/0000-0002-7596-3114)
Institutions
- University of Science and Technology of China (CN)
- Soochow University (TW)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Soochow University (CN)
- University of Chicago (US)
- Betta Pharmaceuticals (China) (CN)
- Institute of High Energy Physics (CN)
- National Engineering Research Center for Nanotechnology (CN)
- National Center for Nanoscience and Technology (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- National Synchrotron Radiation Laboratory (CN)
- University of Chinese Academy of Sciences (CN)
- Zhejiang University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1038/s41467-024-52609-7
- Citations
- 25
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 4.34
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- China Postdoctoral Science Foundation
- Natural Science Foundation of Beijing Municipality
- Postdoctoral Research Foundation of China
- Institute of High Energy Physics
- National Key Research and Development Program of China
- Beijing Synchrotron Radiation Facility
- National Cancer Institute