Mucosal Schwann Cell Hamartoma Mimicking a Colon Polyp: Pathologic Insights

We report a case of a 34-year-old-male who presents with rectal bleeding and finding of a rectal polyp during colonoscopy. Microscopic findings reveal a mucosal based lesion composed of uniform, spindle cells with tapered nuclei, and which expand the lamina propria. No atypia, mitosis, necrosis or associated serrated crypt architecture is seen. The spindle cells exhibit S100 protein positivity. The case highlights the importance of distinguishing gastrointestinal tract spindle cell lesions for accurate diagnosis and appropriate management.