Aging alters the expression of trophic factors and tight junction proteins in the mouse choroid plexus
Our study highlights transcriptional level changes in the CP during aging. The age-related transcriptional changes exhibit similarities as well as gene-specific differences in the CP of males and females. Altered transcription of the water channel protein AQP1 and TJPs could be involved in reduced CSF production during aging. Importantly, reduction in the neurotrophic factors and longevity factor Klotho can play a role in regulating brain aging.
Authors
- Monica Sathyanesan
- Jayanarayanan Sadanandan (ORCID: https://orcid.org/0000-0002-8908-1163)
- Samuel S. Newton
Institutions
- University of South Dakota (US)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12987-024-00574-0
- Citations
- 13
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Institutes of Health