Gut microbiota drives colon cancer risk associated with diet: a comparative analysis of meat-based and pesco-vegetarian diets
These results highlight the protective effects of PVD while reaffirming the carcinogenic properties of MBD diets. In germ-free rats, FMT induced changes reminiscent of dietary effects, including heightened preneoplastic lesions in MBD rats and the transmission of specific diet-related bacterial and metabolic profiles. Importantly, to the best of our knowledge, this is the first study showing that diet-associated cancer risk can be transferred with faeces, establishing gut microbiota as a determinant of diet-associated CRC risk. Therefore, this study marks the pioneering demonstration of faecal transfer as a means of conveying diet-related cancer risk, firmly establishing the gut microbiota as a pivotal factor in diet-associated CRC susceptibility. Video Abstract.
Authors
- Valérie Tondereau
- Claire Maudet
- Carlotta De Filippo (ORCID: https://orcid.org/0000-0002-2222-6524)
- Françoise Guéraud (ORCID: https://orcid.org/0000-0001-5455-1244)
- Antonio Dario Troise (ORCID: https://orcid.org/0000-0001-7635-5244)
- Lisa Giovannelli (ORCID: https://orcid.org/0000-0002-4027-4693)
- Valérie Bézirard (ORCID: https://orcid.org/0009-0007-3516-8021)
- Jacques Dupuy (ORCID: https://orcid.org/0000-0002-8144-154X)
- Mariela Mejia Monroy (ORCID: https://orcid.org/0009-0008-7623-4643)
- Fabrice H.F. Pierre (ORCID: https://orcid.org/0000-0001-6106-8146)
- Serdar Özsezen
- Francesco Vitali (ORCID: https://orcid.org/0000-0001-9125-4337)
- Giovanna Caderni (ORCID: https://orcid.org/0000-0002-0039-4738)
- Sofia Chioccioli (ORCID: https://orcid.org/0000-0003-0279-3246)
- Duccio Cavalieri (ORCID: https://orcid.org/0000-0001-6426-5719)
- Vincenzo Longo
- Jildau Bouwman (ORCID: https://orcid.org/0000-0002-9396-0646)
- Claire Maslo
- Sylvie Chevolleau
- Aurélie Balvay (ORCID: https://orcid.org/0000-0003-1701-4241)
- Niccolò Meriggi (ORCID: https://orcid.org/0000-0002-6908-2169)
- Philippe Gérard (ORCID: https://orcid.org/0000-0001-9521-0067)
- Katia Tortora (ORCID: https://orcid.org/0000-0002-0932-9983)
- Edwin Fouché
- Andrea Scaloni (ORCID: https://orcid.org/0000-0001-9362-8515)
- Charline Buisson
- Nathalie Naud
- Perrine Aubry
- Vassilia Théodorou
- Camille Etienne
Institutions
- Université Toulouse III - Paul Sabatier (FR)
- Netherlands Organisation for Applied Scientific Research (NL)
- École Nationale Vétérinaire de Toulouse (FR)
- AgroParisTech (FR)
- Université Paris-Saclay (FR)
- Microbiologie de l’alimentation au service de la santé (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Toxicologie Alimentaire (FR)
- Istituto per il Sistema Produzione Animale in Ambiente Mediterraneo (IT)
- Institute of Agricultural Biology and Biotechnology (IT)
- National Research Council (IT)
- Deleted Institution
- University of Florence (IT)
Publication Details
- Journal
- Microbiome
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s40168-024-01900-2
- Citations
- 14
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 3.27
Funders
- Fondazione Edmund Mach
- Università degli Studi di Firenze