CSF1 is expressed by the intestinal epithelial cells to regulate Mφ macrophages and maintain epithelial homeostasis and is downregulated in neonates with necrotizing enterocolitis
Intestinal epithelial cells express CSF1 to regulate the resident macrophages, maintain epithelial homeostasis, and resist infection. The abundant CSF1R<sup>+</sup> macrophages in the fetal intestine may overexpress TNF-α upon activation of the TLR4/NF-κB pathway, resulting in epithelial damage and NEC induction.
Authors
- Xu Sun (ORCID: https://orcid.org/0000-0002-8200-654X)
- Shurong Ma (ORCID: https://orcid.org/0000-0002-5733-2183)
- Lingqi Xu
- Jun Du (ORCID: https://orcid.org/0000-0002-2387-0389)
- Huajian Gu (ORCID: https://orcid.org/0000-0002-9670-7320)
- Jian Wang (ORCID: https://orcid.org/0000-0002-4946-9462)
Institutions
- Guiyang Medical University (CN)
- Soochow University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Children's Hospital of Suzhou University (CN)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s12887-024-05047-9
- Citations
- 3
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Soochow University
- Science and Technology Program of Suzhou