Small extracellular vesicles derived from synovial fibroblasts contain distinct miRNA profiles and contribute to chondrocyte damage in osteoarthritis
OA SF sEV regulate chondrocyte inflammatory and remodelling responses. OA SF sEV have unique signatures compared to parental cells which do not alter with IL-1β stimulation. This study provides insight into a novel regulatory mechanism within the OA joint which could inform future targeted therapy.
Authors
- Gary J. Litherland (ORCID: https://orcid.org/0000-0001-5264-0219)
- Anne Crilly (ORCID: https://orcid.org/0000-0002-5980-3612)
- John C. Lockhart (ORCID: https://orcid.org/0000-0001-8115-9205)
- Carl S. Goodyear (ORCID: https://orcid.org/0000-0001-5926-5941)
- John Cole (ORCID: https://orcid.org/0000-0002-6386-766X)
- Sabha Asghar
- Iain B. McInnes (ORCID: https://orcid.org/0000-0002-6462-4280)
- R.M.D. Meek
Institutions
- NHS Lanarkshire (GB)
- Queen Elizabeth University Hospital (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s13075-024-03398-3
- Citations
- 7
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- Arthritis Research UK
- Carnegie Dunfermline Trust
- University of Glasgow
- University of the West of Scotland