Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1
Our study uncovers a novel mechanism regarding immune evasion in melanoma driven by a unique 108aa peptide encoded by circPIAS1 in melanoma that dramatically hinders immunogenic ferroptosis triggered by ICB therapy via modulating the balance between SUMOylation and phosphorylation of STAT1. This work reveals circPIAS1-108aa as a critical factor limiting the immunotherapeutic effects in melanoma and propose a promising strategy for improving ICB treatment outcomes.
Authors
- Yuan‐Zheng Xia (ORCID: https://orcid.org/0000-0002-8526-5184)
- Cheng-mei Xiao
- Lingyi Kong (ORCID: https://orcid.org/0000-0001-5519-1703)
- Xin Zang
- Chengyan Liu (ORCID: https://orcid.org/0000-0001-7411-8069)
- Xiaoyu He (ORCID: https://orcid.org/0000-0001-7233-4067)
- Zhong Chen (ORCID: https://orcid.org/0000-0003-1176-8800)
- Mengyue Wang (ORCID: https://orcid.org/0000-0002-0591-6312)
- Qing Lin
Institutions
- China Pharmaceutical University (CN)
- Tumor Hospital of Guangxi Medical University (CN)
- State Key Laboratory of Natural Medicine
- Nanjing Medical University (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s12943-024-02124-6
- Citations
- 34
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 7.95
Funders
- National Natural Science Foundation of China