Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort
A different IL-1 pathway gene expression was observed in the synovial tissues of early treatment-naïve RA/T2D patients, linked to decreased expression of the ubiquitin-proteasome system. These findings may provide a mechanistic explanation of the observed clinical benefits of IL-1 inhibition in patients with RA and concomitant T2D.
Authors
- Luca Navarini (ORCID: https://orcid.org/0000-0001-8537-1510)
- Marta Vomero (ORCID: https://orcid.org/0000-0001-9744-5628)
- Felice Rivellese (ORCID: https://orcid.org/0000-0002-6759-7521)
- Damiano Currado (ORCID: https://orcid.org/0000-0003-1815-2304)
- Roberto Giacomelli (ORCID: https://orcid.org/0000-0003-0670-9638)
- Costantino Pitzalis (ORCID: https://orcid.org/0000-0003-1326-5051)
- Piero Ruscitti
- Paola Cipriani
Institutions
- Università Campus Bio-Medico (IT)
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- University of L'Aquila (IT)
- Campus Bio Medico University Hospital (IT)
- William Harvey Research Institute (GB)
- IRCCS Humanitas Research Hospital (IT)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-09-28
- DOI
- https://doi.org/10.1186/s13075-024-03392-9
- Citations
- 5
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.17