Enhancing Differential Diagnosis Related to Oxidative Stress, Nitrous Oxide, and Nutrition by Rapid Plasma Homocysteine Measurement
The immunoassay tended to underestimate high-value samples compared to LC-MS/MS, which is a common problem with the competitive methodology. The rapid immunoassay technique is effective for initial screening and early intervention, aiding in the differential diagnosis of conditions related to oxidative stress. Therefore, it is recommended to use the CLIA method for initial screening and confirm with mass spectrometry if there are abnormal samples. Integrating both techniques can enhance diagnostic accuracy and improve patient outcomes.
Authors
- Guillaume Grzych (ORCID: https://orcid.org/0000-0003-2813-0109)
- Céline Tard (ORCID: https://orcid.org/0000-0002-6654-8090)
- Marie Joncquel-Chevalier Curt (ORCID: https://orcid.org/0000-0002-3222-5939)
- Farid Zerimech (ORCID: https://orcid.org/0000-0003-2964-1031)
- Isabelle Kim
- Benjamin Touzé (ORCID: https://orcid.org/0009-0002-4735-5389)
- Marie-Adélaïde Bout
- Claire Douillard (ORCID: https://orcid.org/0000-0002-5714-1600)
- Clarence Descamps
- Thierry Brousseau
Institutions
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
Publication Details
- Journal
- Journal of Xenobiotics
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3390/jox14040075
- Citations
- 2
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Centre hospitalier régional universitaire de Lille