Implementing the Risk Stratification and Clinical Management of Breast Cancer Families Using Polygenic Risk Score Evaluation: A Pilot Study
This study showed that in BC families, the PRS might help to quantify the weight of the genetic familial background, improving the individual risk stratification and contributing to personalized clinical management for carrier and non-carrier women.
Authors
- Vincenzo Cirigliano (ORCID: https://orcid.org/0000-0003-4763-4871)
- Miriam Lucia Carriero (ORCID: https://orcid.org/0000-0001-7339-6024)
- Chantal Tancredi
- Giuliana Longo (ORCID: https://orcid.org/0009-0008-1750-8587)
- Michela Biancolella (ORCID: https://orcid.org/0000-0002-9376-4231)
- Leila Salehi (ORCID: https://orcid.org/0000-0003-1367-8155)
- Oreste Claudio Buonomo (ORCID: https://orcid.org/0000-0002-9531-8737)
- Bibiana Palao
- Barbara Rizzacasa (ORCID: https://orcid.org/0000-0002-4820-4403)
- Vanessa Nicolì (ORCID: https://orcid.org/0000-0003-2751-7352)
- Ilaria Portarena
- Giuseppe Novelli (ORCID: https://orcid.org/0000-0002-7781-602X)
- Chiara Conte (ORCID: https://orcid.org/0000-0002-5530-2167)
- Luis Izquierdo Lopez
Institutions
- University of Rome Tor Vergata (IT)
Publication Details
- Journal
- Journal of Personalized Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3390/jpm14101034
- Citations
- 3
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.65