Knockdown of microglial iron import gene, Slc11a2, worsens cognitive function and alters microglial transcriptional landscape in a sex-specific manner in the APP/PS1 model of Alzheimer’s disease
This work suggests a sex-specific role for microglial iron import gene Slc11a2 in propagating behavioral and cognitive phenotypes in the APP/PS1 model of AD. These data also highlight an association between loss of a DAM-like phenotype in microglia and cognitive deficits in Slc11a2<sup>KD</sup> APP/PS1 female mice. Overall, this work illuminates an iron-related pathway in microglia that may serve a protective role during disease and offers insight into mechanisms behind disease-related sex differences.
Authors
- Kyle R. Schroeder
- Jean‐Philippe Cartailler (ORCID: https://orcid.org/0000-0002-0312-2391)
- Alec T. Kramer
- Shristi Shrestha (ORCID: https://orcid.org/0000-0003-4519-1712)
- Alec Rodriguez
- Alyssa H. Hasty (ORCID: https://orcid.org/0000-0001-7302-8045)
- Fiona E. Harrison (ORCID: https://orcid.org/0000-0003-1121-0647)
- Michael W. Schleh (ORCID: https://orcid.org/0000-0001-9969-6316)
- Katrina Volk Robertson
- Arianna M. Valenti
Institutions
- Vanderbilt University (US)
- Ta Solutions (China) (CN)
- VA Tennessee Valley Healthcare System (US)
- Vanderbilt Health (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12974-024-03238-w
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.99
Funders
- U.S. Department of Veterans Affairs
- Vanderbilt University
- Vanderbilt Memory and Alzheimer's Center
- National Institute on Aging
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Environmental Health Sciences