Differential type I and type III interferon expression profiles in rheumatoid and juvenile idiopathic arthritis
This study revealed differences in IFN expression patterns in RA and JIA, with notable differences between JIA subtypes. The expression levels of <i>IFNκ, IFNγ</i>, <i>IFNλ1 and IFNλ3</i> in JIA suggest specific roles in disease pathology, influenced by disease subtype and joint microenvironment. This study contributes to understanding IFN-mediated mechanisms in arthritis, potentially guiding targeted therapeutic strategies.
Authors
- Anikó Malik (ORCID: https://orcid.org/0000-0001-6702-8436)
- Sarah M. McAlpine (ORCID: https://orcid.org/0000-0002-9298-9682)
- Drew Slauenwhite
- John G. Hanly (ORCID: https://orcid.org/0000-0003-1029-9483)
- Beáta Dérfalvi (ORCID: https://orcid.org/0000-0001-7272-7119)
- Thomas B. Issekutz (ORCID: https://orcid.org/0000-0001-5486-9463)
- Jean S. Marshall (ORCID: https://orcid.org/0000-0002-5642-1379)
Institutions
- Dalhousie University (CA)
- Queen Elizabeth II Health Sciences Centre (CA)
- Izaak Walton Killam Health Centre (CA)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-09-27
- DOI
- https://doi.org/10.3389/fmed.2024.1466397
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nova Scotia Health Research Foundation
- Dalhousie University