Palladium-Catalyzed Branch-Selective Allylic C–H Amination Enabled by Nucleophile Coordination
Regiochemical control is a central subject in the field of synthetic chemistry. Here we unveil an innovative approach for the branch-selective allylic C-H amination of α-alkenes with amine nucleophiles facilitated by phosphoramidite-palladium catalysis. A diverse array of α-alkenes has been effectively utilized to produce a variety of structurally distinct allylamines with moderate to excellent regioselectivity. Furthermore, the asymmetric version of this reaction is feasible through the use of chiral phosphoramidite ligands, albeit with currently modest enantioselectivity.
Authors
- Zhong‐Sheng Nong (ORCID: https://orcid.org/0000-0001-5042-5443)
- Qi‐Lin Zhou (ORCID: https://orcid.org/0000-0002-4700-3765)
- Liu‐Zhu Gong (ORCID: https://orcid.org/0000-0001-6099-827X)
- Pu‐Sheng Wang (ORCID: https://orcid.org/0000-0002-7229-3426)
Institutions
- University of Science and Technology of China (CN)
- Nankai University (CN)
- Hefei National Center for Physical Sciences at Nanoscale (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1021/acs.orglett.4c02935
- Citations
- 8
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- National Natural Science Foundation of China
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- University of Science and Technology of China
- National Key Research and Development Program of China