Inter Arytenoid Granular Cell Tumor of Larynx—A Rare Case Report

Granular cell tumors (GCTs) are uncommon neoplasms, often originating from Schwann cells, with granular cytoplasm being a hallmark feature. Laryngeal GCTs, comprising 3% to 10% of cases, present diagnostic challenges due to their resemblance to squamous cell carcinoma. We present a case of a 46-year-old male with throat pain, diagnosed with a laryngeal GCT. Histopathological examination and immunohistochemistry confirmed the diagnosis. Laryngeal GCTs typically manifest as small, firm submucosal nodules, posing challenges in differentiation from vocal fold polyps. Diagnosis relies on histological examination, with characteristic features including eosinophilic granular cytoplasm and positive staining for specific markers. Malignant transformation, though rare, necessitates vigilant monitoring and accurate diagnosis. Treatment involves complete surgical excision with long-term follow-up to detect recurrence. This case underscores the importance of awareness and accurate diagnosis in managing laryngeal GCTs, ensuring timely intervention and optimal patient outcomes.

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Publication Details

Journal
Ear Nose & Throat Journal
Published
2024-09-27
DOI
https://doi.org/10.1177/01455613241285668
Primary Topic
Tumors and Oncological Cases
Type
article
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article

Inter Arytenoid Granular Cell Tumor of Larynx—A Rare Case Report

Subagar Anbarasan, P Jayaganesh, Sakthimurugan Sankar, Raadhika Shree N
Ear Nose & Throat Journal
Tumors and Oncological Cases
article

Inter Arytenoid Granular Cell Tumor of Larynx—A Rare Case Report

Subagar Anbarasan, P Jayaganesh, Sakthimurugan Sankar, Raadhika Shree N
article en

Abstract

Granular cell tumors (GCTs) are uncommon neoplasms, often originating from Schwann cells, with granular cytoplasm being a hallmark feature. Laryngeal GCTs, comprising 3% to 10% of cases, present diagnostic challenges due to their resemblance to squamous cell carcinoma. We present a case of a 46-year-old male with throat pain, diagnosed with a laryngeal GCT. Histopathological examination and immunohistochemistry confirmed the diagnosis. Laryngeal GCTs typically manifest as small, firm submucosal nodules, posing challenges in differentiation from vocal fold polyps. Diagnosis relies on histological examination, with characteristic features including eosinophilic granular cytoplasm and positive staining for specific markers. Malignant transformation, though rare, necessitates vigilant monitoring and accurate diagnosis. Treatment involves complete surgical excision with long-term follow-up to detect recurrence. This case underscores the importance of awareness and accurate diagnosis in managing laryngeal GCTs, ensuring timely intervention and optimal patient outcomes.

Ear Nose & Throat Journal
Saveetha University (IN)
Good health and well-being
Openalex Percentile: Top 73%
Tumors and Oncological Cases
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Inter Arytenoid Granular Cell Tumor of Larynx—A Rare Case Report — Subagar Anbarasan, P Jayaganesh, et al. · Ear Nose & Throat Journal (2024) | TGRS Research Map | TGRS