Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes
Our findings indicate that the APPswe mutation in iPLCs mimics several aspects of CAA pathology in vitro, suggesting that our iPSC-based vascular cell model could serve as an effective platform for drug discovery aimed to ameliorate vascular dysfunction in AD.
Authors
- Kalevi Trontti (ORCID: https://orcid.org/0000-0002-3797-8163)
- Pinja Kettunen (ORCID: https://orcid.org/0000-0002-3119-4499)
- Ying‐Chieh Wu (ORCID: https://orcid.org/0000-0002-1817-1217)
- Ville Leinonen (ORCID: https://orcid.org/0000-0002-4282-4687)
- Riitta Kauppinen
- Hiramani Dhungana (ORCID: https://orcid.org/0000-0003-3738-5410)
- Taisia Rõlova (ORCID: https://orcid.org/0000-0002-8869-593X)
- Iiris Hovatta (ORCID: https://orcid.org/0000-0002-5990-7892)
- Jari Koıstınaho (ORCID: https://orcid.org/0000-0001-6559-1153)
- Mikko Hiltunen (ORCID: https://orcid.org/0009-0000-3553-5089)
- Johanna Kuusisto (ORCID: https://orcid.org/0000-0001-6550-3176)
- Šárka Lehtonen (ORCID: https://orcid.org/0000-0002-5055-9414)
- Kristine Freude (ORCID: https://orcid.org/0000-0001-9480-2386)
- Markku Laakso (ORCID: https://orcid.org/0000-0002-3394-7749)
Institutions
- University of Copenhagen (DK)
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- Helsinki Institute of Physics (FI)
- Kuopio University Hospital (FI)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s12987-024-00576-y
- Citations
- 4
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- Helsingin Yliopisto
- Academy of Finland
- Biocenter Finland
- Helsinki Institute of Life Science, Helsingin Yliopisto
- H2020 Marie Skłodowska-Curie Actions