Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network

There is no multi-country/multi-language study testing a-priori multivariable associations between non-modifiable/modifiable factors and validated wellbeing/multidimensional mental health outcomes before/during the COVID-19 pandemic. Moreover, studies during COVID-19 pandemic generally do not report on representative/weighted non-probability samples. The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is a multi-country/multi-language survey conducting multivariable/LASSO-regularized regression models and network analyses to identify modifiable/non-modifiable factors associated with wellbeing (WHO-5)/composite psychopathology (P-score) change. It enrolled general population-representative/weighted-non-probability samples (26/04/2020-19/06/2022). Participants included 121,066 adults (age=42±15.9 years, females=64 %, representative sample=29 %) WHO-5/P-score worsened (SMD=0.53/SMD=0.74), especially initially during the pandemic. We identified 15 modifiable/nine non-modifiable risk and 13 modifiable/three non-modifiable protective factors for WHO-5, 16 modifiable/11 non-modifiable risk and 10 modifiable/six non-modifiable protective factors for P-score. The 12 shared risk/protective factors with highest centrality (network-analysis) were, for non-modifiable factors, country income, ethnicity, age, gender, education, mental disorder history, COVID-19-related restrictions, urbanicity, physical disorder history, household room numbers and green space, and socioeconomic status. For modifiable factors, we identified medications, learning, internet, pet-ownership, working and religion as coping strategies, plus pre-pandemic levels of stress, fear, TV, social media or reading time, and COVID-19 information. In multivariable models, for WHO-5, additional non-modifiable factors with |B|>1 were income loss, COVID-19 deaths. For modifiable factors we identified pre-pandemic levels of social functioning, hobbies, frustration and loneliness, and social interactions as coping strategy. For P-scores, additional non-modifiable/modifiable factors were income loss, pre-pandemic infection fear, and social interactions as coping strategy. COH-FIT identified vulnerable sub-populations and actionable individual/environmental factors to protect well-being/mental health during crisis times. Results inform public health policies, and clinical practice.

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Publication Details

Journal
European Neuropsychopharmacology
Published
2024-09-27
DOI
https://doi.org/10.1016/j.euroneuro.2024.07.010
Citations
9
Primary Topic
Mental Health Research Topics
Type
article
Field-Weighted Citation Impact
4.57
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article

Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network

Karol Adam Kamiński, Katharina Domschke, Momoko Kitazawa, Marie‐Odile Krebs et al.
9 citations
European Neuropsychopharmacology
Mental Health Research Topics
4.57
article

Collaborative outcomes study on health and functioning during infection times (COH-FIT): Insights on modifiable and non-modifiable risk and protective factors for wellbeing and mental health during the COVID-19 pandemic from multivariable and network

Karol Adam Kamiński, Katharina Domschke, Momoko Kitazawa, Marie‐Odile Krebs, Michaël Maes, Łukasz Kiszkiel, Soraya Seedat, Celso Arango, Francesco Monaco, Antonia Errázuriz, John M. Kane, John Wells, Brendon Stubbs, Elisabetta Scanferla, Scott B. Teasdale, Natascia Brondino, Diego Hidalgo‐Mazzei, Andreas Meyer‐Lindenberg, Norman Sartorius, Akihiro Takamiya, Judit Balázs, Wojciech M. Marlicz, Andres R. Schneeberger, Aïcha Dahdouh, Samuele Cortese, Ana Inés Machado, Pedro Morgado, Per Vendsborg, Takoua Brahim, Şerban Turliuc, Kai G. Kahl, Chavit Tunvirachaisakul, Andrea Boscutti, Edilberto Peña de León, Eva Andrlíková, Ahmed Mhalla, Sibylle Winter, Aleix Solanes, Tudor Ciuhodaru, Daniel Guinart, Cemal Onur Noyan, André F. Carvalho, Elena Righi, Jihed Sehli, Ta‐Wei Guu, Serge Brand, Philippe Conus, Thitiporn Supasitthumrong, Jeff Daskalakis, Zsolt Unoka, Jerzy Samochowiec, Taishiro Kishimoto, Valentin Matei, Denisa Manková, Raquel Román, Sofia Brissos, Samira Hadi, Mark Weiser, Εmilia Vassilopoulou, Adrian V. Horodnic, Valentina Ciappolino, Joseph Firth, Thérèse van Amelsvoort, Dimitris Efthymiou, Praveenlal Kuttichira, István Bitter, Javier González‐Peñas, Jim van Os, Ruud van Winkel, Guido Cereda, Sabina Heuss, Paweł Sowa, Masoud Sadeghi, Jieting Zhang, Kuan‐Pin Su, Jun Soo Kwon, Thelma Sanchez, Paolo Enrico, Omonefe Joy Seb‐Akahomen, Julie Bourgin, Mara Parellada, Кuanysh Altynbekov, Larisa Movina, Davy Vancampfort, Karolina Skonieczna‐Żydecka, Igor Łoniewski, James Mugisha, Leonardo Zoccante, Giovanni Croatto, Nicola Veronese, Tarek Okasha, Joaquim Raduà, Nicolás Crossley, Christian G. Huber, Lakshmi N. Yatham, Andrés Estradé, Iris E. Sommer, Angela Favaro, Covadonga M. Díaz‐Caneja, Merete Nordentoft, Minah Kim, Ovidiu Alexinschi, Philip A. P. M. Gorwood, Evan Matthews, Georgina Spies, Lydia Fortea, Mark J. Millan, Jess G. Fiedorowicz, Dena Sadeghi Bahmani, Bawo Onesirosan James, Jacopo Demurtas, Mihaela Honciuc, Maryam Moghadasin, Felipe Barreto Schuch, Luana V M Aparicio, Norma Verdolini, Jackie Curtis, Ai Koyanagi, Karolína Janků, José M. Rubio, Teerayuth Rungnirundorn, Alejandro Anselmi, Diego De Leo, Tae Young Lee, Anna Mosina, Xinli Chi, Afzal Javed, Oleg Papsuev, Shunya Kurokawa, Damir Krinitski, Natalia Estrade, Lau Caspar Thygesen, Carlos Gustavo Costardi, Dorien H. Nieman, Nikolay Negay, Christoph Ulrich Correll, Roland von Känel, Samira S. Valvassori, Marco Colizzi, Lin Yang, Miquel À. Fullana, Paolo Fusar‐Poli, Konstantinos Tsamakis, Jhoanne Merlyn Luiz, Eduard Vieta, Sarah Sullivan, Pál Czobor, Philip B. Ward, Wolfgang Marx, André R. Brunoni, Elena Dragioti, Paolo Brambilla, Carlos López‐Jaramillo, Anna M. Moniuszko-Malinowska, Agorastos Agorastos, Sofie Have Hoffmann, Oleg Aizberg, Philippe de Timary, Muhammad Iqbal Afridi, Elena Aschauer, Liviu Oprea, Hatice Aksu, Laís Fonseca, Jari Tiihonen, Andrea Pfennig, Lotfi Gaha, Dragana Ignjatović Ristić, Michael Sand, Yuki Tazawa, Pierluigi Politi, Yasser Abu Jamei, Nesrin Dılbaz, Guilherme V. Polanczyk, Michael Berk, Simon Rosenbaum, Aslı Enez Darçın, Monika Schlögelhofer, Trevor Thompson, Gregor Hasler, Cristiano Gerunda, Saltanat Nurmagambetova, Stefan Borgwardt, Bernardo Ng, Ary Gadelha, Antonia San José Cáceres, Marco Solmi, Maria Marlicz, Kim Q., Golam Rabbani, Gonzalo Arrondo, Dimitris Mavridis, Álvaro Andreu-Bernabeu, Cecilia Cracco, Petru Ifteni, Liye Zou, Alexandra Boloș, Andreas Bechdolf, H.N. Aschauer, Ching-Fang Sun, Pierre‐Michel Llorca, Farshad Sheybani, Jane Elizabeth Hamilton, Nikolaos Koutsouleris, Can Jiao, Xin Yu, Jinhee Lee, Jae Il Shin, Ariful Haque, Jialin Fan, Ramón Arellano, Diego Saccon, Michael Bauer, Vasilios P. Bozikas, Roy Abraham Kallivayalil
article en
9 citations

Abstract

There is no multi-country/multi-language study testing a-priori multivariable associations between non-modifiable/modifiable factors and validated wellbeing/multidimensional mental health outcomes before/during the COVID-19 pandemic. Moreover, studies during COVID-19 pandemic generally do not report on representative/weighted non-probability samples. The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is a multi-country/multi-language survey conducting multivariable/LASSO-regularized regression models and network analyses to identify modifiable/non-modifiable factors associated with wellbeing (WHO-5)/composite psychopathology (P-score) change. It enrolled general population-representative/weighted-non-probability samples (26/04/2020-19/06/2022). Participants included 121,066 adults (age=42±15.9 years, females=64 %, representative sample=29 %) WHO-5/P-score worsened (SMD=0.53/SMD=0.74), especially initially during the pandemic. We identified 15 modifiable/nine non-modifiable risk and 13 modifiable/three non-modifiable protective factors for WHO-5, 16 modifiable/11 non-modifiable risk and 10 modifiable/six non-modifiable protective factors for P-score. The 12 shared risk/protective factors with highest centrality (network-analysis) were, for non-modifiable factors, country income, ethnicity, age, gender, education, mental disorder history, COVID-19-related restrictions, urbanicity, physical disorder history, household room numbers and green space, and socioeconomic status. For modifiable factors, we identified medications, learning, internet, pet-ownership, working and religion as coping strategies, plus pre-pandemic levels of stress, fear, TV, social media or reading time, and COVID-19 information. In multivariable models, for WHO-5, additional non-modifiable factors with |B|>1 were income loss, COVID-19 deaths. For modifiable factors we identified pre-pandemic levels of social functioning, hobbies, frustration and loneliness, and social interactions as coping strategy. For P-scores, additional non-modifiable/modifiable factors were income loss, pre-pandemic infection fear, and social interactions as coping strategy. COH-FIT identified vulnerable sub-populations and actionable individual/environmental factors to protect well-being/mental health during crisis times. Results inform public health policies, and clinical practice.

European NeuropsychopharmacologyVol. 90
Semmelweis University (HU), Linköping University (SE), Eötvös Loránd University (HU), Ain Shams University (EG), South African Medical Research Council (ZA), Griffith University (AU), University of Modena and Reggio Emilia (IT), University of Copenhagen (DK), Alberta Health Services (CA), University of Naples - L'Orientale (IT), Üsküdar University (TR), University of Udine (IT), The University of Sydney (AU), Cliniques Universitaires Saint-Luc (BE), Feinstein Institute for Medical Research (US), University Medical Center Groningen (NL), Université Oran 1 Ahmed Ben Bella (DZ), University of Padua (IT), Seoul National University (KR), University of British Columbia (CA), University of Kragujevac (RS), Medical University of Białystok (PL), Deakin University (AU), University of Fribourg (CH), Inserm (FR), Chulalongkorn University (TH), Carol Davila University of Medicine and Pharmacy (RO), Pontificia Universidad Católica de Chile (CL), Mashhad University of Medical Sciences (IR), University of Monastir (TN), University of Nicosia (CY), University of Southern Denmark (DK), Shenzhen University (CN), Kharazmi University (IR), King's College London (GB), China Medical University (TW), University of Basel (CH), University of Milan (IT), Utrecht University (NL), Yonsei University (KR), University of Ioannina (GR), South London and Maudsley NHS Foundation Trust (GB), Peking University (CN), University of Zurich (CH), Keio University (JP), Université Paris Cité (FR), Aristotle University of Thessaloniki (GR), Heidelberg University (DE), University of Pavia (IT), Medical University of Warsaw (PL), Sheba Medical Center (IL), Jubilee Mission Medical College and Research Institute (IN), Ottawa Hospital (CA), Mental Health Research UK (GB), University Medical Center Freiburg (DE), Instituto de Salud Carlos III (ES), Jinnah Sindh Medical University (PK), Niuvanniemi Hospital (FI), University Hospital Heidelberg (DE), Pushpagiri Medical College (IN), Seoul National University Hospital (KR), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT), University of Manchester (GB), Hospital General Universitario Gregorio Marañón (ES), FHNW University of Applied Sciences and Arts Northwestern Switzerland (CH), University Medical Center Utrecht (NL), Grigore T. Popa University of Medicine and Pharmacy (RO), Transylvania University of Brașov (RO), University Town of Shenzhen (CN), UNSW Sydney (AU), Universidade Federal de Santa Maria (BR), Maastricht University (NL), Medizinische Hochschule Hannover (DE), Universidad de Antioquia (CO), University of Bristol (GB), IEEE Computer Society (US), University of California San Diego (US), Kermanshah University of Medical Sciences (IR), Mental Health Foundation (GB), Centro de Investigación Biomédica en Red de Salud Mental (ES), Belarusian Medical Academy of Post-Graduate Education (BY), University Hospital of Zurich (CH), Universidad Católica del Uruguay (UY), GZO Spital Wetzikon (CH), University of Clermont Auvergne (FR), Central Institute of Mental Health (DE), Hellenic Agency for Local Development and Local Government (GR), The Geneva Association (CH), Hospital Clínic de Barcelona (ES), Integrierte Psychiatrie Winterthur (CH), Alberta Cancer Foundation (CA), European Biomedical Research Institute of Salerno (IT), Clinica de Pneumologie Iaşi (RO), Psykiatrien i Region Syddanmark (DK), Ospedale per gli Infermi (IT), RED Consulting (Norway) (NO), China Medical University Hospital (TW), Asociación Mexicana de Psicología y Desarrollo Comunitario (MX), Kazakhstan Medical University (KZ), Centre Hospitalier Universitaire de Clermont-Ferrand (FR), Parc Sanitari Sant Joan de Déu (ES), Institut de Psychiatrie et Neurosciences de Paris (FR), Parc de Salut (ES), Mind Australia (AU), FHU Neurovasc (FR), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR), Moscow Regional Psychiatry Hospital No.5 (RU), Child Health Research Foundation (BD), ABS Consulting (United States) (US), Pusan National University Yangsan Hospital (KR), Amsterdam University Medical Centers (NL), Irrua Specialist Teaching Hospital (NG), Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo (IT), Tees, Esk and Wear Valleys NHS Foundation Trust (GB), The University of Texas Health Science Center (US), Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES), University Hospital Carl Gustav Carus (DE), Peking University Sixth Hospital (CN), Psychiatric Medical Center (AM), Hôpital de l'enfance (CH), Universitäre Psychiatrische Kliniken Basel (CH), National Institute of Mental Health (CZ), University of Southampton (GB), Kyambogo University (UG), Mindgardens Neuroscience Network, Clienia AG, University of Greenwich (GB), Carilion Clinic (US), University of Palestine (PS), Istanbul University (TR), Universitat de Barcelona (ES), Waterford Institute of Technology (IE), Adnan Menderes University (TR), Universidade do Extremo Sul Catarinense (BR), Charité - Universitätsmedizin Berlin (DE), University of Glasgow (GB), Pomeranian Medical University (PL), University of Veterinary and Animal Sciences (PK), Ludwig-Maximilians-Universität München (DE), Universidad de Navarra (ES), Universidade Federal de São Paulo (BR), University of Palermo (IT), University of Lübeck (DE), University of Lausanne (CH), KU Leuven (BE), University of Minho (PT)
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Mental Health Research Topics
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