Nickel-Catalyzed Enantioselective Reductive <i>N</i>-Cyclization–Thiolation Reaction of Alkene-Tethered Oxime Esters and Disulfides

Asymmetric aza-Heck cyclization and coupling reactions offer efficient access to enantioenriched <i>N</i>-heterocycles, yet the current studies focus primarily on sequential C-N and C-C bond formation. Herein, we report an enantioselective reductive aza-Heck cyclization followed by a C-S coupling sequence, ultimately yielding sulfide-containing enantioenriched pyrrolines. The reaction is conducted under mild conditions and tolerates broad functionalities including alkynes, phenols, anilines, amides, nitriles, and bromides.