Adipose-derived stem cells apoptosis rejuvenate radiation-impaired skin in mice via remodeling and rearranging dermal collagens matrix
This study demonstrated that ADSCs underwent substantial apoptosis upon local skin transplantation, and paradoxically, this apoptosis is essential for their efficacy in promoting the regeneration of late radiation-impaired skin. Mechanically, transplanted ADSCs could promote the remodeling and rearrangement of radiation-damaged dermal collagen matrix.
Authors
- Yufan Zhu (ORCID: https://orcid.org/0000-0003-4378-7424)
- Yunjun Liao (ORCID: https://orcid.org/0000-0001-5264-3962)
- Xu Liu (ORCID: https://orcid.org/0009-0006-9326-0195)
- Xihang Chen (ORCID: https://orcid.org/0000-0002-6698-9080)
Institutions
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s13287-024-03904-z
- Citations
- 4
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China