Pooled analysis of the MANTICO2 and MONET randomized controlled trials comparing drug efficacy for early treatment of COVID-19 during Omicron waves
NMV/r was superior to TGM/CGM in reducing hospital admission or death in clinically vulnerable patients with SARS-CoV-2 infection treated within 5 days of symptoms' onset. No significant difference in symptom prevalence over time across the arms was found.
Authors
- Andrea Santoro (ORCID: https://orcid.org/0000-0001-7959-2958)
- Alessandro Cozzi Lepri (ORCID: https://orcid.org/0000-0001-7305-4382)
- Loredana Sarmati (ORCID: https://orcid.org/0000-0003-1452-0333)
- Giulia Rosini (ORCID: https://orcid.org/0000-0001-8863-4670)
- Andrea Antinori (ORCID: https://orcid.org/0000-0003-2121-4684)
- Evelina Tacconelli (ORCID: https://orcid.org/0000-0003-2010-4977)
- Emanuele Nicastri (ORCID: https://orcid.org/0000-0002-5606-8712)
- Federico De Zottis (ORCID: https://orcid.org/0000-0001-9040-2000)
- Simone Lanini (ORCID: https://orcid.org/0000-0002-6743-4001)
- Omar Simonetti (ORCID: https://orcid.org/0000-0002-4016-4136)
- Fulvia Mazzaferri (ORCID: https://orcid.org/0000-0002-3907-108X)
- Alessandra Vergori (ORCID: https://orcid.org/0000-0001-6944-0686)
- Valentina Mazzotta (ORCID: https://orcid.org/0000-0002-0240-7504)
- Ilaria Mastrorosa (ORCID: https://orcid.org/0000-0003-1944-662X)
- Carlo Tascini (ORCID: https://orcid.org/0000-0001-9625-6024)
- Enrico Girardi (ORCID: https://orcid.org/0000-0001-8182-5896)
- Alessia Savoldi (ORCID: https://orcid.org/0000-0003-1873-5323)
- Massimo Mirandola (ORCID: https://orcid.org/0000-0002-2342-5867)
- Laura Rovigo
- Gaia Maccarrone
- Lorenzo Tavernaro
- Anna Maria Cattelan
Institutions
- University of Rome Tor Vergata (IT)
- University of Verona (IT)
- University of Udine (IT)
- University of Padua (IT)
- National Institute for Health and Care Research (GB)
- Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
- Center for Prevention and Treatment of Infections (US)
- Ospedale San Paolo (IT)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
- University College London (GB)
Publication Details
- Journal
- Journal of Infection
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.jinf.2024.106294
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Ministero della Salute
- Agenzia Italiana del Farmaco, Ministero della Salute