Adipose stem cells regulate lipid metabolism by upregulating mitochondrial fatty acid β-oxidation in macrophages to improve the retention rate of transplanted fat
ASCs increased the retention rate of transplanted fat by upregulating mitochondrial FAO to promote M2 polaration in macrophages. In addition, ASCs up-regulate mitochondrial FAO by paracrine effect to reduce foam cells formation and promote M2 transformation in macrophages in vitro.
Authors
- Xinyao Chen (ORCID: https://orcid.org/0000-0003-2421-1649)
- Yuyang Du (ORCID: https://orcid.org/0000-0002-4798-7397)
- Jiani Lin
- Tingting Guo (ORCID: https://orcid.org/0000-0002-4748-6699)
- Rou Li (ORCID: https://orcid.org/0000-0001-7266-6213)
- Sai Luo (ORCID: https://orcid.org/0000-0002-4220-3805)
- Ye Li (ORCID: https://orcid.org/0000-0001-7727-0875)
- Qing Wang (ORCID: https://orcid.org/0009-0003-7328-8762)
- Jiapeng Li (ORCID: https://orcid.org/0000-0003-4321-1150)
- Jiayue Fu
Institutions
- Harbin Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Nanfang Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Heilongjiang University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s13287-024-03953-4
- Citations
- 5
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China
- Foundation for the Author of National Excellent Doctoral Dissertation of the People's Republic of China