Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment
We report a suggestive genetic association at the rs79229764 locus with TRS and show that genetic liability for schizophrenia is positively associated with TRS. These results suggest a candidate locus for future follow-up studies to elucidate the molecular underpinnings of TRS. Our findings further demonstrate the value of both single variant and polygenic association analyses for TRS prediction.
Authors
- Ibrahim A. Akkouh
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-4461-3568)
- Robert L. Smith (ORCID: https://orcid.org/0000-0001-6789-7076)
- Srdjan Djurovic (ORCID: https://orcid.org/0000-0002-8140-8061)
- Hasan Çağın Lenk (ORCID: https://orcid.org/0000-0003-4724-7396)
- Elise Koch (ORCID: https://orcid.org/0000-0003-3727-4470)
- Kevin S. O’Connell (ORCID: https://orcid.org/0000-0002-6865-8795)
- Espen Molden
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- Diakonhjemmet Hospital (NO)
Publication Details
- Journal
- Human Genomics
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s40246-024-00673-x
- Citations
- 5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.75
Funders
- European Commission
- Universitetet i Oslo
- Norges Forskningsråd
- Helse Sør-Øst RHF