Evaluation of the impact of customized serum-free culture medium on the production of clinical-grade human umbilical cord mesenchymal stem cells: insights for future clinical applications
Considering the substantial funding and time required for cell-based drug development, our results underscore the importances of comprehensively optimizing the composition of medium for the specific disease prior to conducting clinical trials of cell-based therapies. The criteria for selecting culture medium should be based on the requirements of the target disease for cellular function. In addition, we provide a way to formulate different customized SFM, which is beneficial for the development of cell therapy industry.
Authors
- Beibei Ni (ORCID: https://orcid.org/0009-0000-3502-7957)
- Jinqing Li (ORCID: https://orcid.org/0000-0003-4635-2661)
- Lan Zhao (ORCID: https://orcid.org/0000-0003-0270-870X)
- Wenjuan Yang (ORCID: https://orcid.org/0000-0001-7270-8356)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-5803-2556)
- Rui Liu (ORCID: https://orcid.org/0000-0002-5002-7311)
- Zhuangbin Zheng
- Lijun Bi
- Wei Yu (ORCID: https://orcid.org/0000-0003-2550-5833)
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Experimental Station (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Guangzhou First People's Hospital (CN)
- Guangzhou Chemistry (China) (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s13287-024-03949-0
- Citations
- 8
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- National Natural Science Foundation of China