Human uncultured adipose-derived stromal vascular fraction shows therapeutic potential against osteoarthritis in immunodeficient rats via direct effects of transplanted M2 macrophages
The M2Φ in the transplanted SVF directly affected recipient tissue, enhancing the secretion of growth factors and chondrocyte-protecting cytokines, and partially improving chondrocytes and joint homeostasis. These findings indicate that the SVF is as an effective option for regenerative therapy for OA, with mechanisms different from those of ADSCs.
Authors
- Kensuke Wada
- Akira Saitoh
- Takehiko Matsushita (ORCID: https://orcid.org/0000-0001-6616-0398)
- Shinya Hayashi (ORCID: https://orcid.org/0000-0003-4308-9845)
- Tomoyuki Matsumoto (ORCID: https://orcid.org/0000-0003-4587-0029)
- Kemmei Ikuta (ORCID: https://orcid.org/0000-0003-1678-4543)
- Kensuke Anjiki (ORCID: https://orcid.org/0000-0002-4343-2730)
- Yuichi Kuroda
- Ryosuke Kuroda (ORCID: https://orcid.org/0000-0001-5097-7264)
- Takafumi Hiranaka (ORCID: https://orcid.org/0000-0003-4916-6071)
- Takuma Maeda (ORCID: https://orcid.org/0000-0002-8852-0208)
- Hideki Iwaguro
- Yoshihito Suda
- Yuma Onoi (ORCID: https://orcid.org/0000-0002-0624-508X)
- Masanori Tsubosaka (ORCID: https://orcid.org/0000-0001-6702-1242)
- Naoki Nakano (ORCID: https://orcid.org/0000-0003-4067-9233)
- Shotaro Tachibana (ORCID: https://orcid.org/0000-0001-7680-8071)
- Tomoyuki Kamenaga
- Satoshi Sobajima
Institutions
- Osaka Nishi Clinic (JP)
- Takatsuki General Hospital (JP)
- Kobe University (JP)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s13287-024-03946-3
- Citations
- 12
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.64