Cytokine priming enhances the antifibrotic effects of human adipose derived mesenchymal stromal cells conditioned medium
In vitro, MSC-CM promote fibrosis resolution, an effect enhanced following MSC cytokine priming. Specifically, MSC-CM reduces fibrogenic myofibroblasts through apoptosis, senescence, and by enhancing ECM degradation. Future studies will establish the in vivo relevance of MSC priming to fibrosis resolution.
Authors
- Dominique Farge (ORCID: https://orcid.org/0000-0002-4041-1352)
- Marianela Brizio
- Benoît Brilland (ORCID: https://orcid.org/0000-0001-9622-4014)
- David Langlais (ORCID: https://orcid.org/0000-0003-4429-0110)
- Mathieu Mancini (ORCID: https://orcid.org/0000-0002-4981-7121)
- Shirley Zhu (ORCID: https://orcid.org/0009-0005-8492-7915)
- Dieter Peter Reinhardt (ORCID: https://orcid.org/0000-0001-6535-9872)
- Inés Colmegna (ORCID: https://orcid.org/0000-0002-8091-8334)
- Maximilien Lora
- Sydney Joy
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- McGill University Health Centre (CA)
- Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- McGill Genome Centre (CA)
- Centre d'Immunologie et des Maladies Infectieuses (FR)
- Université d'Angers (FR)
- McGill University (CA)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1186/s13287-024-03916-9
- Citations
- 9
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.94
Funders
- McGill University Health Centre
- Canadian Institutes of Health Research