IL-22 and IL-23 regulate the anticryptococcal response during Cryptococcus deuterogattii infection
Cryptococcosis is a neglected fungal disease that causes many deaths annually, is primarily caused by <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> species. They are environmental fungus that engages lung pneumonia and a severe systemic infection. The rising incidence of affected immunocompetent hosts, particularly by the aggressive <i>Cryptococcus deuterogattii</i> (R265), underscores the urgency to understand factors influencing its dissemination. The immunopathogenesis of R265 infection is incompletely understood. Therefore, we investigate the role of IL-22 and IL-23 cytokines during R265 cryptocococcosis. Our findings highlight the crucial role of IL-22 and IL-23 cytokines in lung barrier homeostasis, preventing excessive lung damage. IL-22 not only prevents neutrophil infiltration and IL-17A production but also facilitates eosinophil lung infiltration. Ultimately, this study contributes vital insights into the selective role of IL-22 and IL-23 cytokines in immune activation and tissue regulation during the aggressive R265 lung and systemic infection.
Authors
- Lycia de Brito‐Gitirana (ORCID: https://orcid.org/0000-0002-5580-6939)
- Joyce Cristina Guimarães-de-Oliveira (ORCID: https://orcid.org/0000-0001-8673-4563)
- Ariel Gomes
- Israel Diniz-Lima (ORCID: https://orcid.org/0000-0003-0176-3520)
- Débora Decotè-Ricardo (ORCID: https://orcid.org/0000-0001-8761-7641)
- Leonardo Freire‐de‐Lima (ORCID: https://orcid.org/0000-0003-3013-3173)
- Herbert Leonel de Matos Guedes (ORCID: https://orcid.org/0000-0002-3819-3069)
- Alexandre Morrot (ORCID: https://orcid.org/0000-0001-9432-9701)
- Fernanda Ferreira Cruz (ORCID: https://orcid.org/0000-0001-9443-3648)
- Célio Geraldo Freire-de-Lima (ORCID: https://orcid.org/0000-0002-4148-3657)
- Elias Barbosa da Silva-Júnior (ORCID: https://orcid.org/0000-0001-7953-6948)
- Danielle Oliveira Nascimento
- Mayck Medeiros
- Idália Maria Ferreira-Dos-Santos
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal Rural do Rio de Janeiro (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- iScience
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.isci.2024.111054
- Citations
- 4
- Primary Topic
- Fungal Infections and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação Oswaldo Cruz
- Universidade Federal do Rio de Janeiro