Protective activity of hirsutidin in high-fat intake and streptozotocin-induced diabetic rats: In silico and in vivo study
Hirsutidin may have an evidential hypoglycemic outcome and may exhibit potent antidiabetic activity in HFD/STZ-induced T2DM in rats. Treatment with hirsutidin significantly improved glycemic control, lipid metabolism, oxidative stress, inflammation, and liver function. Additionally, it normalized dysregulated levels of adiponectin, leptin, and resistin. Molecular docking confirmed its strong binding affinity to key diabetic targets.
Authors
- Salwa D. Al-Qahtani (ORCID: https://orcid.org/0009-0007-2223-3031)
- Naif A. R. Almalki (ORCID: https://orcid.org/0000-0002-1142-607X)
- Faisal Imam (ORCID: https://orcid.org/0000-0003-2285-6806)
- Sami I. Alzarea (ORCID: https://orcid.org/0000-0003-4007-4023)
- Fahad A. Al‐Abbasi (ORCID: https://orcid.org/0000-0001-5609-4913)
- Ehssan Moglad (ORCID: https://orcid.org/0000-0002-1076-9740)
- Nadeem Sayyed (ORCID: https://orcid.org/0000-0003-0517-4934)
- Imran Kazmi (ORCID: https://orcid.org/0000-0003-1881-5219)
- Muhammad Afzal (ORCID: https://orcid.org/0000-0003-2570-3223)
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
- King Abdulaziz University (SA)
- Majmaah University (SA)
- Jouf University (SA)
- King Saud University (SA)
- Glocal University (IN)
- University of Jeddah (SA)
- Batterjee Medical College
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38625
- Citations
- 8
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 3.73
Funders
- King Saud University