Sleeve-gastrectomy results in improved metabolism and a massive stress response of the liver proteome in a mouse model of metabolic dysfunction-associated steatohepatitis
The rapid weight loss and decrease of hepatic fat after SG lead to a proinflammatory response in the liver in the early phase after surgery, which changes to a more moderate immune response in the long-term. We suggest a preoperative risk stratification and postoperative surveillance depending on the histopathological findings.
Authors
- Karsten Große (ORCID: https://orcid.org/0000-0003-1013-6297)
- Sophia M. Schmitz (ORCID: https://orcid.org/0000-0001-6732-1595)
- Patrick H. Alizai (ORCID: https://orcid.org/0000-0001-7872-3776)
- Christian Preisinger (ORCID: https://orcid.org/0000-0003-1233-9063)
- Thorsten Cramer (ORCID: https://orcid.org/0000-0002-6462-239X)
- Daniel Heise (ORCID: https://orcid.org/0000-0001-6923-0849)
- Karl Peter Rheinwalt (ORCID: https://orcid.org/0000-0001-9375-874X)
- Jochen Nolting (ORCID: https://orcid.org/0000-0002-1419-3830)
- Andreas Kroh (ORCID: https://orcid.org/0000-0002-7836-7844)
- Julia Andruszkow
- Roman Eickhoff (ORCID: https://orcid.org/0000-0001-6064-7859)
- Tom Florian Ulmer (ORCID: https://orcid.org/0000-0003-0788-0357)
- Ulf P. Neumann (ORCID: https://orcid.org/0000-0002-3831-8917)
- Saskia Köhne
Institutions
- Essen University Hospital (DE)
- Universitätsklinikum Aachen (DE)
- Gemeinschaftskrankenhaus Havelhöhe (DE)
- St. Franziskus Hospital (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38678
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.77
Funders
- B. Braun-Stiftung
- Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen