Postnatal deletion of Phlpp1 in chondrocytes delays post-traumatic osteoarthritis in male mice
Postnatal deletion of Phlpp1 in chondrocytes attenuates DMM-induced cartilage damage and subchondral bone sclerosis but does not prevent pain-related behaviors. Intra-articular injection of Phlpp inhibitors delays mechanical allodynia in Phlpp1-CKO<sub>AgcERT</sub> mice. These data indicate that Phlpp1 in chondrocytes affects articular cartilage structure after injury, but pain-related behaviors are controlled by Phlpp1 or Phlpp2 in other cell types.
Authors
- Samantha Weaver (ORCID: https://orcid.org/0000-0001-6034-214X)
- Elizabeth L. Zars
- Elizabeth W. Bradley (ORCID: https://orcid.org/0000-0002-8814-5524)
- Katherine M. Arnold (ORCID: https://orcid.org/0000-0002-5831-9036)
- Jennifer J. Westendorf (ORCID: https://orcid.org/0000-0002-4464-6108)
- Manuela Oviedo
- Eduardo Peralta-Herrera
Institutions
- University of Minnesota (US)
- Mayo Clinic in Arizona (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.ocarto.2024.100525
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases