Senolytics cocktail dasatinib and quercetin alleviate chondrocyte senescence and facet joint osteoarthritis in mice
Our outcomes revealed that D+Q, the renowned combination used for senolytic treatment, alleviate the progression of LFJ OA. The utilization of D+Q as a senolytic demonstrates a novel and promising alternative for LFJ OA treatment.
Authors
- Yi Sun (ORCID: https://orcid.org/0000-0003-0516-9000)
- Zhide Liu (ORCID: https://orcid.org/0000-0001-8200-7780)
- Guoyu Dai (ORCID: https://orcid.org/0000-0002-6726-8541)
- Tianding Wu (ORCID: https://orcid.org/0000-0001-8118-8102)
- Yuxin Jin (ORCID: https://orcid.org/0009-0002-6776-1341)
- Rundong He
- Jianzhong Hu
- Chunyue Duan (ORCID: https://orcid.org/0000-0002-6874-4853)
- Yong Cao (ORCID: https://orcid.org/0000-0002-9618-4734)
- Jinyun Zhao
- Lifu Zheng
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- The Spine Journal
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.spinee.2024.09.017
- Citations
- 15
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 7.05
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Science and Technology Major Project of Guangxi