Pharmacological and toxicological characteristics of baicalin in preventing spontaneous abortion and recurrent pregnancy loss: A multi-level critical review
We explored the bioavailability, targeting and efficacy of BA from a new perspective (optimization of the BA delivery system, organoid studies based on BA, potential effects of BA on uterine flora and bioactive components). Finally, we propose a multimodal stereo sequencing study of biologically active components based on pathological dynamics incorporating single-cell RNA sequencing, spatially resolved transcriptomics, and single-cell multimodal omics to delve deeper into the fetal-preserving mechanism of BA and to promote the application of BA in clinical practice.
Authors
- Xiaoyan Zheng
- Hang Zhou (ORCID: https://orcid.org/0000-0003-1776-3736)
- Linwen Deng (ORCID: https://orcid.org/0000-0002-4100-8581)
- Yong Feng (ORCID: https://orcid.org/0000-0002-0908-1623)
- Yi Yang (ORCID: https://orcid.org/0000-0003-3602-7048)
- Qian Zeng (ORCID: https://orcid.org/0000-0001-6981-9768)
- Yue Jin
Institutions
- Mianyang Central Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38633
- Citations
- 1
- Primary Topic
- Biological Activity of Diterpenoids and Biflavonoids
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Tongji University
- Department of Science and Technology of Sichuan Province