Treadmill exercise improves cerebral ischemia injury by regulating microglia polarization via downregulation of MMP12
Our data demonstrate that treadmill exercise could improve the inflammatory microenvironment in the brain after ischemic stroke, which may be caused by inhibition of MMP12 expression. MMP12 suppression in primary microglia could remodel microglia immune functions. In summary, this study may provide novel insights into the immune mechanism of exercise training for stroke and suggests potential targets for therapeutic approaches.
Authors
- Yajie Li (ORCID: https://orcid.org/0000-0003-2121-6057)
- Y. Fan (ORCID: https://orcid.org/0000-0002-3786-5169)
- Yatao Yin
- Chunchu Deng (ORCID: https://orcid.org/0000-0002-5533-6009)
- Xiaojian Cao (ORCID: https://orcid.org/0000-0001-9710-5113)
- Jia Xu
- Qiuzhi Zhou
- Hong Chen (ORCID: https://orcid.org/0000-0003-3478-6139)
- Song Zhang (ORCID: https://orcid.org/0000-0002-5801-5374)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.intimp.2024.113210
- Citations
- 7
- Primary Topic
- Stroke Rehabilitation and Recovery
- Type
- article
- Field-Weighted Citation Impact
- 1.75
Funders
- National Natural Science Foundation of China