Bioinformatics analysis identifies WNK1 gene as a potential biomarker for cholangiocarcinoma diagnosis and immune infiltration
Based on network analysis and the summary of previous studies, it was proposed that CHOL tumor cells secrete CXCL5, leading to neutrophil recruitment to the tumor microenvironment. Vascular endothelial growth factor A (VEGFA) released by the infiltrating neutrophils is suggested to promote overexpression of WNK1 by tumor cells, activating the VEGFA downstream pathway to promote angiogenesis and tumor progression.
Authors
- Caijun Zha
- Wenjing Zhang (ORCID: https://orcid.org/0000-0002-4507-5351)
- Lei Yan (ORCID: https://orcid.org/0000-0001-7075-0438)
- Qi Sun
- Xiangrong Meng
- Xianli Lei
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Baoshan University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Genetic Engineering and Biotechnology
- Published
- 2024-09-27
- DOI
- https://doi.org/10.1016/j.jgeb.2024.100426
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China